How to access the I2C devices connected to LS I2C2 bus viz Zynq Development Kit?

Yes, it is possible to access the LS I2C2 bus through the Zynq development platform via the PMOD connector. However, a few hardware modifications are required to isolate the Layerscape processor from the I2C bus.

Multi-master operation on the I2C bus is not supported in this scenario.

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Please find the detailed product information here:
Virtex™ UltraScale+™ System on Module